Nowadays, infertility is a common hindrance among couples, which is making most couples deprived of the prominent and beloved happiness of their lives while distressing their lifestyle upside down. Though conceiving can be a complicated process, it doesn't mean you cannot improve the level of infertility in your life.
aromatase inhibitor, arimidex (anastrozole), shown to be effective therapy in male infertility in those with high aromatase activity. The effect was seen through improved Testosterone:Estradiol ratio through aromatase inhibition.
The problem of male infertility continues to grow. New study finds that from 1973 to 2011, sperm count among men in North America, Europe, Australia, and New Zealand drop by 50-60%.
aromatase inhibition in men to increase Testosterone:Estradiol ratio. Men with infertility have a low Testosterone:Estradiol ratio. Aromatase inhibitors inhibit Testosterone to Estradiol conversion
Glyphosate, component of Roundup is well known to be an endocrine disruptor. This rat study describes the mechanism of disruption of the Sertoli cells resulting in male infertility. In addition to the disruption of spermatogenesis, Glyphosate was shown to deplete glutathione levels compromising detoxification. If that is not enough, oxidative damage marker TBARS was elevated.
Study points to association of low Estradiol and spermatogenesis in males in infertile couples. The authors eluded to the association of low Estradiol with low Testosterone, and BMI which is the likely etiology. Low BMI will result in low aromatase activity. For men, the majority of Estradiol production occurs from Testosterone via aromatase activity. Estradiol likely exists in a "U" shaped pattern of benefit: to low hinders optimal physiologic function and contributes to inflammation and disease in men.
Research-based ways to boost male infertility and increase sperm count include various lifestyle changes, such as exercising regularly, Get enough vitamin C, Minimize your stress levels, Quit smoking and limit alcohol, Avoid toxic chemicals in the workplace, Eat more greens. Consider ashwagandha, Aim for a healthy weight, balance zinc levels, etc, Read the full blog.
Men with infertility associated with 2.3 fold higher risk of death. The factors evaluated were semen volume, sperm concentration, sperm motility, total sperm count, total motile sperm count. Those that have 2 or more positive parameters were associated with increased death compared to those with normal semen analysis.
The evidence suggests that antioxidant supplementation in subfertile males may improve the outcomes of live birth and pregnancy rate for subfertile couples undergoing ART cycles
2012 study that shows a slight uptick in sperm count/concentration in Danish men. However, as the conclusion states, on 25% have optimal sperm quality. When you look at the numbers deeper, the current general population sperm count/concentration was lower than that of men of infertile couples from 1940-1943 cohort. Additionally, when the general population sperm count/concentration was lower than that of compared recent fertile men.
Case study of 1 of a man with remote history of anabolic steroid use and current azoospermia. HCG therapy for 3 months led to resolution of infertility.
Indiscriminate use of testosterone in men can have irreversible effects. This study showed that decreases sperm count, as a result of testosterone therapy in young men, can be irreversible.